This 2014 study investigates the synergistic effects of the soybean-derived peptide lunasin combined with cytokines IL-2 and IL-12 on natural killer (NK) cells in the context of lymphoma immunotherapy. Lunasin enhances NK cell activation, increasing the expression of IFNγ and granzyme B, leading to improved cytotoxicity against lymphoma cells. Notably,
This 2017 review explores melatonin’s potential as a preventive and therapeutic agent against various cancers, including breast, prostate, gastric, and colorectal cancers. Melatonin exhibits multiple anticancer mechanisms: it acts as a potent antioxidant, modulates MT1 and MT2 melatonin receptors, induces apoptosis, regulates pro-survival signaling pathways and tumor metabolism, inhibits angiogenesis
This study examines the role of the Bowman-Birk protease inhibitor (BBI) in enhancing the oral bioavailability and cancer-preventive activity of lunasin, a soy-derived peptide known for its epigenetic modulation properties. Lunasin binds to deacetylated histones and inhibits histone acetylation, thereby regulating gene expression involved in tumorigenesis. However, its effectiveness is
This 2021 review explores the therapeutic potential of high-dose intravenous vitamin C (IVC) in oncology, emphasizing its role as a multi-targeting agent. Pharmacologic doses of IVC exert pro-oxidative effects that selectively induce cancer cell apoptosis by generating hydrogen peroxide in the tumor microenvironment. The review outlines additional mechanisms, including modulation
