Well Referenced

Tag: disease prevention

Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline

This 2024 guideline updates the 2011 recommendations, focusing on vitamin D use for disease prevention in individuals without established indications for treatment or 25(OH)D testing. Key recommendations include: (1) Empiric vitamin D supplementation is suggested for children and adolescents aged 1–18 years to prevent nutritional rickets and potentially reduce respiratory

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June 26, 2025 No Comments

Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the Global Burden of Disease Study 2013

This 2016 systematic review and dose-response meta-analysis incorporated data from 174 prospective cohort studies to evaluate the relationship between physical activity and the incidence of breast cancer, colon cancer, type 2 diabetes, ischemic heart disease, and ischemic stroke. It demonstrated an inverse, non-linear relationship between total physical activity (measured in

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June 26, 2025 No Comments

Chronic inflammation in the etiology of disease across the life span

This systematic review discusses the role of chronic inflammation in the etiology of age-related diseases, including cardiovascular, neurological, and metabolic disorders. It explores how inflammation accelerates aging and contributes to the development of various chronic diseases by activating immune pathways and releasing pro-inflammatory cytokines. The study highlights interventions targeting these

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June 26, 2025 No Comments

The Key Role of Mitochondrial Function in Health and Disease

This systematic review highlights the fundamental role of mitochondrial function in maintaining human health and its involvement in the development of chronic diseases such as type 2 diabetes, cardiovascular disease, Alzheimer’s, cancer, and metabolic syndrome. Mitochondrial dysfunction stems from genetic mutations, aging, infections, and sedentary behavior. The review emphasizes the

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June 26, 2025 No Comments

Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics

This study explores the role of urinary 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker for oxidative stress and its association with increased risks of cancer, atherosclerosis, and diabetes. Elevated urinary 8-OHdG levels were observed in patients with various cancers, human atherosclerotic plaques, and diabetic individuals with hyperglycemia, highlighting its potential as a

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June 26, 2025 No Comments

Dehydroepiandrosterone, Cancer, and Aging

The review article titled “Dehydroepiandrosterone, Cancer, and Aging” (Aging and Disease, 2022, PMID: 35430962) evaluates the potential benefits of dehydroepiandrosterone (DHEA), the most abundant circulating steroid hormone, in preventing and managing age-related diseases, particularly cancer and metabolic disorders. It highlights DHEA’s proposed mechanism of action, including inhibition of glucose-6-phosphate dehydrogenase

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June 26, 2025 No Comments