A randomized, double-blinded clinical trial investigated the efficacy and safety of low-level light therapy (LLLT) using 660 nm red LEDs and 411 to 777 nm white LEDs for treating facial wrinkles in 52 adult female participants. Over 12 weeks, participants received daily facial irradiation with 5.17 J of either red
This review explores the role of bioidentical hormone replacement therapy (BHRT) in counteracting skin aging caused by hormonal decline. Hormonal deficiencies contribute to decreased skin elasticity, hydration, and increased wrinkling. BHRT, which uses hormones structurally identical to those naturally produced in the body, has been found to improve skin thickness,
This observational study evaluated the effectiveness of narrowband blue light therapy (409-419 nm) for mild to moderate facial acne in 30 participants. Over four weeks, subjects received eight treatment sessions, with assessments at weeks 5, 8, and 12. The study found a significant reduction in inflammatory acne lesions by week
This randomized controlled trial compared the effectiveness and side effects of red light (RL) and blue light (BL) therapies for mild-to-moderate acne vulgaris in 28 participants. At a two-week follow-up, RL therapy showed a 36.2% reduction in total acne lesions, compared to 30.7% for BL (p > 0.05). RL therapy
This pilot study evaluated the combined effects of fractional resurfacing and photodynamic therapy (PDT) with aminolevulinic acid (ALA) on perioral wrinkles in four female patients. After two sessions of fractional resurfacing with the Fraxel SR device, ALA-PDT was applied to one half of the perioral area, showing enhanced improvements in
This study investigated the effects of organic light-emitting diode (OLED) therapy compared to traditional LED therapy for skin rejuvenation and wound healing. In vitro, OLED irradiation significantly enhanced collagen production and reduced matrix metalloproteinases (MMPs) levels, surpassing the effects of LED therapy. Both treatments accelerated wound healing and increased growth
A prospective split-face clinical trial assessed the efficacy and safety of a home-use light-emitting diode (LED) device emitting at 637 and 854 nm for facial rejuvenation. Twenty-four participants with photoaged skin applied the device to the left side of their faces twice weekly for eight weeks. Skin elasticity, hydration, texture,
Estrogen plays a crucial role in skin health by maintaining collagen levels, enhancing skin thickness, increasing moisture retention through acid mucopolysaccharides and hyaluronic acid, and supporting wound healing, particularly in postmenopausal women. Both topical and systemic estrogen therapies have been shown to increase skin collagen content, while hormone replacement therapy
This review article discusses the use of bioidentical hormone therapy (BHT) for managing menopausal symptoms and its application in dermatology. BHT, designed to mimic natural hormones, is widely marketed for its potential skin benefits, such as anti-aging effects. However, there is limited scientific evidence supporting these claims, and dermatologists are
This review examines the role of glutathione as a skin-lightening agent, focusing on its mechanism of action, efficacy, and safety. Glutathione inhibits tyrosinase, shifting melanin production from eumelanin (darker pigment) to pheomelanin (lighter pigment), and is available in oral, topical, and intravenous forms. While three randomized controlled trials suggest that
