Well Referenced

Tag: critical care

β-Nicotinamide mononucleotide activates NAD+/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic mice

This study investigates the therapeutic potential of β-Nicotinamide Mononucleotide (NMN) in sepsis-associated encephalopathy (SAE), a complication of sepsis characterized by cognitive dysfunction. Using a cecal ligation and puncture (CLP) model in male C57BL/6J mice, researchers administered NMN intraperitoneally at a dose of 500 mg/kg. NMN treatment elevated NAD+ and SIRT1

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June 26, 2025 No Comments

Stable Gastric Pentadecapeptide BPC 157 Therapy: Effect on Reperfusion Following Maintained Intra-Abdominal Hypertension (Grade III and IV) in Rats

This preclinical study assessed the therapeutic effects of BPC 157, a stable gastric pentadecapeptide, in a rat model of severe intra-abdominal hypertension (IAH) classified as Grade III and IV. IAH was induced and maintained to simulate critical clinical conditions, followed by reperfusion. Rats treated with BPC 157 exhibited significant improvements

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June 26, 2025 No Comments

Vitamin C May Reduce the Duration of Mechanical Ventilation in Critically Ill Patients: A Meta-Regression Analysis

This 2020 meta-regression analysis by Hemilä and Chalker evaluated the impact of vitamin C supplementation on the duration of mechanical ventilation in critically ill patients. The study analyzed data from multiple trials and found that vitamin C administration was associated with a significant reduction in ventilation duration, particularly in patients

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June 26, 2025 No Comments

Randomised controlled trial for high-dose intravenous zinc as adjunctive therapy in SARS-CoV-2 (COVID-19) positive critically ill patients: trial protocol

This article outlines the protocol for a randomized, double-blind, placebo-controlled trial designed to assess the safety and efficacy of high-dose intravenous zinc as an adjunctive therapy in critically ill patients with confirmed SARS-CoV-2 infection. Conducted at a single center in Australia, the study aims to enroll adult patients admitted to

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June 26, 2025 No Comments

Safety and Dose Escalation Study of Intravenous Zinc Supplementation in Pediatric Critical Illness

This phase I dose-escalation study evaluated the safety and pharmacokinetics of intravenous zinc supplementation in critically ill pediatric patients. Conducted at a single center, the study enrolled 10 children aged 1–17 years with systemic inflammatory response syndrome (SIRS) or sepsis. Participants received escalating doses of intravenous zinc chloride (0.25, 0.5,

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June 26, 2025 No Comments

Methylene Blue: Magic Bullet for Vasoplegia?

This systematic review evaluates the use of methylene blue (MB) in managing vasoplegic shock, particularly in critical care, liver transplantation, and cardiac anesthesia. While MB has shown consistent blood pressure improvement in small studies and case reports, its effect on mortality and oxygen delivery remains inconclusive. The review stresses the

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June 26, 2025 No Comments

Methylene Blue in Septic Shock: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis assessed the use of methylene blue (MB) for managing septic shock in critically ill adults. The findings suggest that MB may reduce short-term mortality, the need for vasopressors, and hospital stay duration, with no significant increase in adverse events. However, the evidence is of low

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June 26, 2025 No Comments

A randomized trial comparing triiodothyronine (T3) with thyroxine (T4) for hemodynamically unstable brain-dead organ donors

The randomized controlled trial titled “A randomized trial comparing triiodothyronine (T3) with thyroxine (T4) for hemodynamically unstable brain-dead organ donors” (Clinical Transplantation, 2019, PMID: 30689222) investigated the effects of T3 versus T4 hormone therapy on hemodynamic stability in brain-dead organ donors. The study found that T3 therapy improved cardiac function

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June 26, 2025 No Comments

A randomized trial of oral DHEA treatment for sexual function, well-being, and menopausal symptoms in postmenopausal women with low libido

This observational study explored the use of triiodothyronine (T3) therapy in hospitalized patients with hypothyroidism, demonstrating its effectiveness in rapidly normalizing thyroid hormone levels and improving clinical outcomes compared to levothyroxine (T4). The study found that T3 had a faster onset of action, making it particularly beneficial for critically ill

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June 26, 2025 No Comments