This large-scale prospective cohort study analyzed data from over 210,000 U.S. adults across three cohorts: the Nurses’ Health Study (NHS), NHS II, and the Health Professionals Follow-up Study (HPFS), spanning up to 32 years. The study assessed the inflammatory potential of participants’ diets using the empirical dietary inflammatory pattern (EDIP)
This population-based cohort study from France included 7,484 community-dwelling adults aged 65 years and older without a history of vascular events. It aimed to assess whether lipid-lowering drugs (mainly statins and fibrates) reduce the long-term risk of stroke and coronary heart disease (CHD) in a primary prevention setting. Over a
This comprehensive systematic review and meta-analysis investigated the relationship between exposure to environmental toxic metals—arsenic, lead, cadmium, mercury, and copper—and the incidence of cardiovascular disease (CVD), including coronary heart disease (CHD) and stroke. Drawing from 37 studies with over 348,000 participants, the analysis revealed that higher levels of arsenic, lead,
This ACMG practice guideline concludes that routine testing for MTHFR polymorphisms in evaluating thrombophilia provides no significant clinical benefits. Despite earlier hypotheses suggesting a link between MTHFR polymorphisms and increased risk for coronary heart disease, venous thromboembolism, and pregnancy loss, recent meta-analyses have disproven these associations. As a result, MTHFR
This review explores the cardiovascular benefits of standardized hawthorn (Crataegus spp.) extracts, particularly in managing mild chronic heart failure. Clinical trials with over 4,000 patients have shown significant improvements, as well as vasoprotective and cardioprotective effects. Hawthorn extracts also have potential applications for treating endothelial dysfunction, atherosclerosis, coronary heart disease,
This cohort study from the Multi-Ethnic Study of Atherosclerosis (MESA) examined whether coronary artery calcium (CAC) progression predicts future coronary heart disease (CHD) events. Over a median follow-up of 7.6 years in 6,778 participants aged 45 to 84, annual CAC increases were linked to higher CHD risk. Those with a
This systematic review evaluates the efficacy of chelation therapy for coronary heart disease by reviewing all clinical investigations, including both controlled and uncontrolled studies. The review concluded that there is limited evidence supporting the effectiveness of chelation therapy, primarily based on case reports and case series. Only two controlled clinical
This review article examines the relationship between dietary magnesium intake and cardiovascular disease (CVD), emphasizing that low magnesium levels are linked to an increased risk of conditions such as hypertension, coronary heart disease, and stroke. The article highlights evidence from epidemiological studies showing that higher magnesium intake, particularly through food
A review published in Gynecological Endocrinology analyzed the Women’s Health Initiative (WHI) findings on hormone replacement therapy (HRT) in postmenopausal women, focusing on the effects of conjugated equine estrogens (CEE) alone versus CEE combined with medroxyprogesterone acetate (MPA). The study highlighted that the high prevalence of metabolic syndrome among participants
This randomized controlled trial analyzed data from the Women’s Health Initiative (WHI) to assess the impact of hormone therapy (HT) on cardiovascular disease (CVD) risk based on age and time since menopause. The study included 27,347 postmenopausal women aged 50 to 79 years, randomized to receive HT or placebo. Findings
