Well Referenced

Tag: Combination Treatment

Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction

This clinical trial investigated the effects of Coenzyme Q10 (CoQ10) supplementation on pain reduction in fibromyalgia patients receiving pregabalin. The study found that adding CoQ10 to pregabalin therapy significantly reduced pain, improved mitochondrial function, and decreased brain hyperactivity, suggesting a synergistic effect in managing fibromyalgia symptoms. CoQ10, a key component

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June 26, 2025 No Comments

The Antioxidant and HDAC-Inhibitor α-Lipoic Acid: Is Synergistic with Exemestane in Estrogen Receptor-Positive Breast Cancer Cells

The in vitro study examined the synergistic effects of the aromatase inhibitor exemestane and the antioxidant/HDAC inhibitor α-lipoic acid on estrogen receptor-positive (ER+) breast cancer cells (MCF-7 and T47D). The combination treatment significantly reduced cell viability, promoted apoptosis, and modulated key apoptosis-related proteins, increasing p21, APAF-1, BIM, and FOXO1 while

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June 26, 2025 No Comments

Depressive symptoms in climacteric women are related to menopausal symptom intensity and partner factors

The study titled “Depression and the menopause: why antidepressants are not enough?” (PMID: 19465674) explores the multifactorial etiology of postmenopausal depression, highlighting its increased severity, insidious progression, and resistance to standard antidepressant treatments. The authors suggest that combining hormone therapy (HT) with antidepressants may enhance treatment efficacy, accelerate symptom improvement,

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June 26, 2025 No Comments