Well Referenced

Tag: cognitive enhancement

Ameliorative Effects of Phytomedicines on Alzheimer’s Patients

This review investigates the neuroprotective effects of six phytomedicines—Panax ginseng, Ginkgo biloba, Bacopa monnieri, Withania somnifera, Curcuma longa, and Lavandula angustifolia—against Alzheimer’s disease (AD). The study highlights how these plants and their active components can help reverse neurological changes in AD, such as amyloid-beta plaques and neurofibrillary tangles, and improve

Read More »
June 26, 2025 No Comments

Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds

This review highlights the health-promoting properties of Hericium erinaceus (Lion’s Mane) mushroom, focusing on its bioactive compounds such as erinacines and hericenones. The mushroom is shown to have a wide range of therapeutic benefits, including neuroprotection, cognitive enhancement, anti-inflammatory, antioxidative, and immunostimulating effects. It also demonstrates potential in managing mood

Read More »
June 26, 2025 No Comments

Administration of phosphatidylcholine increases brain acetylcholine concentration and improves memory in mice with dementia

This animal study investigated the effects of phosphatidylcholine (PC) supplementation on memory performance and brain acetylcholine levels in dementia-model and normal mice. Dementia-model mice exhibited significantly poorer memory and lower brain acetylcholine concentrations than normal controls (p < 0.05). After 45 days of daily PC administration (100 mg), dementia-model mice

Read More »
June 26, 2025 No Comments

Neuroprotective and Neurological/Cognitive Enhancement Effects of Curcumin after Brain Ischemia Injury with Alzheimer’s Disease Phenotype

This review discusses the neuroprotective and cognitive enhancement effects of curcumin in the context of brain ischemia and Alzheimer’s disease (AD). It highlights curcumin’s ability to reduce inflammation, improve antioxidant activity, and modulate key proteins linked to Alzheimer’s pathology, such as amyloid precursor protein and tau. The findings suggest that

Read More »
June 26, 2025 No Comments

L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial

This randomized, double-blind, placebo-controlled trial investigated the effects of L-carnitine supplementation on physical and mental fatigue, cognitive function, and body composition in centenarians. Participants receiving 2 grams of levocarnitine daily experienced significant reductions in fat mass (-1.80 kg vs. +0.6 kg; P < 0.01), increases in muscle mass (+3.80 kg

Read More »
June 26, 2025 No Comments

The neurobiology of acetyl-L-carnitine

This systematic review examines the neurobiological effects of acetyl-L-carnitine (ALC), a derivative of L-carnitine, focusing on its role in neurotransmitter modulation, neuroprotection, and cognitive enhancement. The review suggests that ALC has the potential to influence neurotransmitter systems, provide neuroprotection, and improve cognitive functions, making it potentially useful in treating neurological

Read More »
June 26, 2025 No Comments

Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease

This review explores the potential clinical applications of curcumin, a polyphenol derived from turmeric, in preventing and diagnosing Alzheimer’s disease (AD). Curcumin exhibits antioxidant, anti-inflammatory, and neuroprotective properties that may help delay or prevent neurodegenerative diseases by interacting with β-amyloid plaques and tau proteins, key pathological markers of AD. Additionally,

Read More »
June 26, 2025 No Comments

From Mitochondrial Function to Neuroprotection-an Emerging Role for Methylene Blue

This review explores the potential neuroprotective role of methylene blue (MB), particularly its ability to enhance mitochondrial function in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, stroke, and traumatic brain injury. MB acts as an alternative electron carrier in the mitochondrial electron transport chain, improving ATP production and reducing

Read More »
June 26, 2025 No Comments

Dehydroepiandrosterone (DHEA) supplementation for cognitive function

The systematic review titled “Dehydroepiandrosterone (DHEA) supplementation for cognitive function in healthy elderly individuals” (Cochrane Database of Systematic Reviews, 2001, DOI: 10.1002/14651858.CD000304) analyzed data from three randomized controlled trials with a total of 145 healthy participants aged 55 and older. The review found no significant cognitive benefits from DHEA supplementation

Read More »
June 26, 2025 No Comments