Well Referenced

Tag: cerebral ischemia

NAD⁺ Deficiency Is a Common Central Pathological Factor of a Number of Diseases and Aging: Mechanisms and Therapeutic Implications

This review article highlights the critical role of nicotinamide adenine dinucleotide (NAD⁺) deficiency in various diseases and aging processes. It discusses how NAD⁺ deficiency is observed in models of cerebral ischemia, myocardial ischemia, diabetes, and aging. The deficiency results from factors like poly(ADP-ribose) polymerase-1 (PARP-1) activation, decreased nicotinamide phosphoribosyltransferase (Nampt)

Read More »
June 26, 2025 No Comments

Dose-related neuroprotective versus neurodamaging effects of estrogens in rat cerebral ischemia: a systematic analysis

This 2009 systematic analysis reviewed 66 studies on estrogen’s effects in rat models of cerebral ischemia. The findings revealed that estrogen’s impact is dose-dependent: low doses administered via injections or silastic capsules exhibited neuroprotective effects, whereas high doses delivered through slow-release pellets were associated with increased ischemic damage. The study

Read More »
June 26, 2025 No Comments

Substantiation for the Use of Curcumin during the Development of Neurodegeneration after Brain Ischemia

The article titled “Substantiation for the Use of Curcumin during the Development of Neurodegeneration after Brain Ischemia” (International Journal of Molecular Sciences, 2020, PMID: 31947633) is a review that explores the potential neuroprotective effects of curcumin in the context of brain ischemia. It highlights curcumin’s antioxidant, anti-inflammatory, and anti-apoptotic properties,

Read More »
June 26, 2025 No Comments

Alternative mitochondrial electron transfer as a novel strategy for neuroprotection

Methylene blue (MB) demonstrates neuroprotective potential by acting as an alternative electron carrier in the mitochondrial electron transport chain, bypassing dysfunctions in complexes I and III. This mechanism enhances mitochondrial respiration, reduces reactive oxygen species, and prevents cellular energy failure. In animal models of Parkinson’s disease and cerebral ischemia, MB

Read More »
June 26, 2025 No Comments

Progesterone receptor replenishment in T47D human breast cancer cells. Roles of protein synthesis and hormone metabolism

This study examines the neuroprotective effects of progesterone following cerebral ischemia and reperfusion injury in rats. The findings show that progesterone administration significantly preserves mitochondrial function and reduces neuronal apoptosis in the brain regions affected by ischemia. These results suggest that progesterone may offer therapeutic benefits for mitigating ischemic brain

Read More »
June 26, 2025 No Comments