Well Referenced

Tag: cardiovascular disease

Methylenetetrahydrofolate reductase: biochemical characterization and medical significance

The article discusses the role of methylenetetrahydrofolate reductase (MTHFR) in folate metabolism and homocysteine regulation, highlighting the C677T polymorphism and its association with various diseases, including cardiovascular disease, Alzheimer’s, depression, and neural tube defects. The review explains how this genetic variant influences folate metabolism, affecting health outcomes, and emphasizes the

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June 26, 2025 No Comments

Inflammation and hemostasis biomarkers and cardiovascular risk in the elderly: the Cardiovascular Health Study

This observational study followed 4,510 older adults over 9 years and found that elevated levels of specific biomarkers related to inflammation and hemostasis, such as IL-6, CRP, D-dimer, homocysteine, WBC count, factor VIII, and lipoprotein(a), were significantly associated with increased cardiovascular risk. The study also noted gender differences in biomarker

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June 26, 2025 No Comments

Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association

This 2003 practice guideline published in Circulation (DOI: 10.1161/01.cir.0000052939.59093.45) by the CDC and AHA evaluates the clinical relevance of inflammatory markers, particularly high-sensitivity C-reactive protein (hs-CRP), in assessing cardiovascular disease (CVD) risk. It concludes that hs-CRP is a useful tool for identifying low-grade systemic inflammation and may enhance cardiovascular risk

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June 26, 2025 No Comments

Obesity and inflammation: epidemiology, risk factors, and markers of inflammation

This 2013 review article published in International Journal of Endocrinology (DOI: 10.1155/2013/678159) explores the intricate link between obesity and chronic systemic inflammation. It details how obesity triggers an immune response in adipose tissue, leading to increased production of pro-inflammatory cytokines such as IL-6 and TNF-alpha, and acute-phase proteins like C-reactive

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June 26, 2025 No Comments

The relation between healthy lifestyle changes and decrease in systemic inflammation in patients with stable cardiovascular disease

This cohort study examined how lifestyle modifications—such as smoking cessation, weight loss, increased physical activity, and alcohol moderation—affect systemic inflammation, as measured by C-reactive protein (CRP) levels, in patients with stable cardiovascular disease (CVD). The study found that smoking cessation, weight loss, and physical activity significantly reduced CRP levels, with

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June 26, 2025 No Comments

Beneficial Effects of Resveratrol Administration-Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions

This review article explores the beneficial effects of resveratrol, focusing on its potential mechanisms in cardiovascular conditions. It highlights resveratrol’s ability to improve endothelial function, reduce oxidative stress, and modulate lipid metabolism, which are critical factors in cardiovascular health. The review suggests that resveratrol may offer therapeutic benefits by activating

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June 26, 2025 No Comments

Berberine, a Herbal Metabolite in the Metabolic Syndrome: The Risk Factors, Course, and Consequences of the Disease

This review article examines the pharmacological effects of berberine, a herbal metabolite, in managing metabolic syndrome and associated conditions like type 2 diabetes, obesity, atherosclerosis, cardiovascular diseases, and polycystic ovary syndrome (PCOS). Berberine improves insulin sensitivity, reduces blood glucose, lowers LDL cholesterol, mitigates inflammation by inhibiting COX-2, and induces apoptosis

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June 26, 2025 No Comments

High-sensitivity C-reactive protein as cardiovascular risk marker in patients with diabetes mellitus

This review explores the potential of high-sensitivity C-reactive protein (hsCRP) as an independent predictor of cardiovascular events in patients with diabetes mellitus. By assessing systemic inflammation, hsCRP levels offer clinicians a valuable tool for identifying diabetic individuals at elevated cardiovascular risk, improving risk stratification and informing targeted preventive strategies.

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June 26, 2025 No Comments

Increased levels of high sensitive C-reactive protein in patients with chronic rheumatic valve disease: evidence of ongoing inflammation

This observational study found elevated high-sensitivity C-reactive protein (hs-CRP) levels in patients with chronic rheumatic valve disease (CRVD) compared to those with prosthetic valves and healthy controls, suggesting ongoing inflammation in CRVD. Monitoring hs-CRP levels may provide insights into disease progression and highlight the potential for anti-inflammatory strategies to manage

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June 26, 2025 No Comments

Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease

This review discusses the concept of “inflamm-ageing,” a chronic low-grade inflammation associated with aging that contributes to vascular aging, atherosclerosis, and age-related cardiovascular diseases (CVDs). It highlights how inflammasome activation and reduced anti-inflammatory mechanisms accelerate vascular dysfunction, and it suggests that targeting these inflammatory pathways may help prevent or treat

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June 26, 2025 No Comments