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Tag: cardiac remodeling

New Therapeutic Approach to Heart Failure Due to Myocardial Infarction Based on Targeting Growth Hormone-Releasing Hormone Receptor

This 2015 preclinical study by Kanashiro-Takeuchi et al. investigated the effects of growth hormone-releasing hormone (GHRH) agonists on myocardial infarction (MI)-induced heart failure. Using rodent models, the researchers administered GHRH agonists (JI-38, MR-356, and MR-409) and observed significant improvements in cardiac function, including reduced infarct size, enhanced vascular density, increased

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June 26, 2025 No Comments

NAD⁺: A Big Player in Cardiac and Skeletal Muscle Remodeling and Aging

This review highlights the pivotal role of NAD⁺ in cardiac and skeletal muscle health, emphasizing its antioxidant and anti-aging properties. Replenishment of NAD⁺ has been shown to ameliorate muscle dystrophy in mice by enhancing mitochondrial function and extending lifespan. Additionally, NAD⁺ supplementation improves cardiac relaxation in heart failure models by

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June 26, 2025 No Comments