Well Referenced

Tag: cadmium

A Review on Coordination Properties of Thiol-Containing Chelating Agents Towards Mercury, Cadmium, and Lead

This review analyzes the coordination behavior and therapeutic potential of thiol-based chelators—DMSA, DMPS, BAL, and α-lipoic acid—against toxic metals mercury (Hg), cadmium (Cd), and lead (Pb). It outlines how these metals interact preferentially with sulfur-containing ligands due to their classification as soft or borderline acids. DMSA is noted for its

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June 26, 2025 No Comments

Environmental Toxic Metal Contaminants and Risk of Cardiovascular Disease: Systematic Review and Meta-Analysis

This comprehensive systematic review and meta-analysis investigated the relationship between exposure to environmental toxic metals—arsenic, lead, cadmium, mercury, and copper—and the incidence of cardiovascular disease (CVD), including coronary heart disease (CHD) and stroke. Drawing from 37 studies with over 348,000 participants, the analysis revealed that higher levels of arsenic, lead,

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June 26, 2025 No Comments

Endothelial Dysfunction Induced by Cadmium and Mercury and its Relationship to Hypertension

This review article explores the mechanistic links between cadmium (Cd) and mercury (Hg) exposure, endothelial dysfunction, and hypertension. Both metals are shown to induce oxidative stress and reduce nitric oxide (NO) bioavailability, impairing endothelial-dependent vasodilation and promoting vascular stiffness. Cd and Hg disrupt calcium signaling, increase reactive oxygen species (ROS),

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June 26, 2025 No Comments

Heavy metal toxicity: An update of chelating therapeutic strategies

This 2019 review by Kim et al. provides a comprehensive overview of heavy metal toxicity and the role of chelation therapy in its management. The authors discuss how heavy metals such as arsenic, cadmium, copper, iron, lead, and mercury can induce oxidative stress by generating free radicals and depleting antioxidant

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June 26, 2025 No Comments

The Benefits of Pre- and Post-challenge Urine Heavy Metal Testing: Part 1

This 2009 article by Walter J. Crinnion discusses the clinical utility of measuring heavy metals in urine both before and after administering a chelating agent. Pre-challenge urine samples reflect recent exposures to metals like lead and mercury, while post-challenge samples, collected after using a mobilizing agent, indicate the total body

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June 26, 2025 No Comments

Metallic Air Pollutants and Breast Cancer Risk in a Nationwide Cohort Study

This 2019 prospective cohort study analyzed data from 50,884 women enrolled in the Sister Study to assess the association between airborne metal exposure and breast cancer risk. Utilizing the 2005 EPA National Air Toxics Assessment, researchers estimated residential exposure to ten metals, including mercury, cadmium, and lead. Over a mean

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June 26, 2025 No Comments

Metals and breast cancer

This 2013 review explores the role of metalloestrogens—metals that can activate estrogen receptors—in breast cancer development. It highlights cadmium as a well-studied example, demonstrating its ability to mimic estrogen and promote tumor growth. The review discusses how these metals, including cadmium, arsenite, and others, can bind to estrogen receptor-α, leading

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June 26, 2025 No Comments