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Tag: bupropion

Combination Therapy with Naltrexone and Bupropion for Obesity Reduces Total and Visceral Adiposity

This 2013 study assessed the impact of combined naltrexone/bupropion therapy on body composition in 107 obese adults over 24 weeks. Participants were randomized to receive placebo, naltrexone monotherapy, bupropion monotherapy, or one of three naltrexone/bupropion combinations. Body composition was measured using dual-energy X-ray absorptiometry and computed tomography. The combination therapy

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June 26, 2025 No Comments

Naltrexone Sustained-Release/Bupropion Sustained-Release for the Management of Obesity: Review of the Data to Date

This 2014 systematic review evaluates the efficacy and safety of the naltrexone sustained-release/bupropion sustained-release (NB SR) combination, marketed as Contrave®, for obesity management. Clinical trials indicate a placebo-subtracted weight loss of approximately 4.5%, comparable to other anti-obesity medications. The combination targets central nervous system pathways to reduce appetite and food

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June 26, 2025 No Comments

The Female Sexual Response: Current Models, Neurobiological Underpinnings and Agents Currently Approved or Under Investigation for the Treatment of Hypoactive Sexual Desire Disorder

A systematic review examined the neurobiological mechanisms behind hypoactive sexual desire disorder (HSDD) in women, focusing on the balance between excitatory and inhibitory pathways. The study highlighted the roles of various neuromodulators, such as norepinephrine, dopamine, oxytocin, and serotonin, in sexual desire. Treatments like buspirone, bupropion, and bremelanotide aim to

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June 26, 2025 No Comments