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Tag: brain metabolism

Choline-containing phospholipids: relevance to brain functional pathways

This comprehensive review examines the biological functions and therapeutic potential of choline-containing phospholipids (CCPLs), particularly CDP-choline (citicoline) and choline alphoscerate (α-GPC), in brain health. CCPLs are vital components of cell membranes and precursors to acetylcholine, essential for cholinergic neurotransmission. They also contribute to membrane repair, signal transduction, and methylation pathways.

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June 26, 2025 No Comments

Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat.

This study titled “Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat” provides compelling evidence that glutathione (GSH), a key antioxidant, is actively transported into the brain through a specific, saturable, carrier-mediated mechanism rather than by passive diffusion. Using carotid artery injection in rats, 35S-labeled glutathione

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June 26, 2025 No Comments

Neurosteroids: biosynthesis, metabolism and function of pregnenolone and dehydroepiandrosterone in the brain

The study “Neurosteroids: biosynthesis, metabolism and function of pregnenolone and dehydroepiandrosterone in the brain” examines the biosynthesis, metabolism, and functional roles of neurosteroids such as pregnenolone (P) and dehydroepiandrosterone (D) in the brain. It discusses how these neurosteroids accumulate in different forms, including unconjugated steroids, sulfates, and fatty acid esters,

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June 26, 2025 No Comments

Methylene blue as a cerebral metabolic and hemodynamic enhancer

This study explores the effects of methylene blue (MB) on brain metabolism and blood flow, highlighting its potential therapeutic role in neurological conditions. The administration of MB significantly increased mitochondrial complex activity, enhancing oxygen consumption and glucose uptake in brain cells. Animal models showed that MB also improved cerebral blood

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June 26, 2025 No Comments

Methylene blue improves brain oxidative metabolism and memory retention in rats

This study investigated the effects of methylene blue (MB) on brain oxidative metabolism and memory retention in rats. The results showed that MB administration significantly enhanced cytochrome c oxidase activity, which boosted brain oxidative metabolism. Rats treated with MB exhibited a marked improvement in spatial memory retention, with treated rats

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June 26, 2025 No Comments

Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders

The study “Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders” (Cell Metabolism, 2022) explores the role of pregnenolone production in hypothalamic pro-opiomelanocortin (POMC) neurons in regulating recognition memory, particularly under metabolic stress conditions like obesity and type 2 diabetes. Researchers found that a short-term high-fat diet impaired

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June 26, 2025 No Comments