This 2004 case-control study by Chevrier et al. investigated the association between ozonated drinking water and bladder cancer risk in France. Analyzing data from 281 cases and 272 controls with at least 70% residential exposure data over 30 years, the study found that longer exposure to ozonated water correlated with
This review examines the potential association between sodium-glucose cotransporter 2 (SGLT2) inhibitors and cancer risk. Early clinical trials of dapagliflozin indicated an imbalance in reported cases of breast and bladder cancer, raising safety concerns. However, these findings lacked statistical significance and may be attributed to early cancer detection rather than
This systematic review and meta-analysis assessed the risk of second primary malignancies following radiotherapy for prostate cancer. Analyzing 21 observational studies, the research found that radiotherapy, particularly external beam radiotherapy, was associated with increased risks of bladder (adjusted hazard ratio [HR] 1.67), colorectal (HR 1.79), and rectal cancers (HR 1.79)
This 2021 in vitro study examined the impact of chronic naltrexone exposure on bladder cancer cell lines (T24 and MB49). It demonstrated that successive treatment enhanced proliferation, migration, and invasion while inhibiting apoptosis. Mechanistically, naltrexone induced epithelial-mesenchymal transition (EMT) by downregulating epithelial markers (E-cadherin, CK19) and upregulating mesenchymal markers (N-cadherin,
This 2017 study analyzed cancer mortality in Region II of northern Chile, where residents experienced high arsenic exposure in drinking water from 1958 until a significant reduction in 1970. Despite the decrease in exposure, mortality rates for lung, bladder, and kidney cancers remained elevated even 40 years later. Specifically, from
This 2018 review examines the complex role of nitric oxide (NO) in cancer biology, particularly in prostate and bladder cancers. While low levels of NO can support tumor progression through angiogenesis and immune evasion, high concentrations can trigger apoptosis and sensitize tumors to chemotherapy and radiotherapy. The paper evaluates various
This 2015 retrospective case series evaluated the potential of high-dose Viscum album (European mistletoe) extract therapy in preventing bladder cancer recurrence. Eight patients with resectable bladder cancer (7 non-muscle-invasive, 1 muscle-invasive) received subcutaneous injections of high-dose Viscum album extract between 2006 and 2012. Prior to this therapy, patients had experienced
This study investigates the effect of artesunate on bladder cancer cells, showing that it induces apoptosis through the regulation of miR-16, which in turn downregulates the expression of COX-2, an enzyme associated with cancer cell survival and inflammation. The findings suggest that artesunate could be a promising therapeutic agent for
This 2015 retrospective observational study (The Permanente Journal, PMID: 26517439) investigated the use of high-dose, fever-inducing Viscum album (European mistletoe) extract as an adjunctive therapy to prevent bladder cancer recurrence in eight patients, seven of whom had nonmuscle-invasive disease. Over a median follow-up of 48.5 months, five patients showed a
