Well Referenced

Tag: anticancer

Resveratrol Inhibits the Growth of Gastric Cancer by Inducing G1 Phase Arrest and Senescence in a Sirt1-Dependent Manner

This 2013 study explores the antiproliferative effects of resveratrol on gastric cancer cells through a Sirt1-dependent pathway. Resveratrol treatment caused significant G1 phase arrest and cellular senescence without inducing apoptosis. Mechanistically, it downregulated cyclin D1, CDK4, and CDK6 while upregulating p21 and p16, halting cell cycle progression. In vivo experiments

Read More »
June 26, 2025 No Comments

The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug

This 2018 review explores the repositioning of ivermectin, traditionally an antiparasitic agent, as a novel anticancer drug. The article highlights ivermectin’s ability to target multiple molecular pathways critical to cancer cell survival and proliferation. Mechanistically, ivermectin inhibits P-glycoprotein to overcome drug resistance, acts on chloride ion channels to induce apoptosis,

Read More »
June 26, 2025 No Comments

Bioactive Compounds from Vegetal Organs of Taraxacum Species (Dandelion) with Biomedical Applications: A Review

This review explores the bioactive compounds found in Taraxacum officinale (dandelion), such as polyphenols, flavonoids, carotenoids, terpenes, and coumarins, which contribute to its therapeutic properties. The review highlights dandelion’s anti-inflammatory, anticancer, antimicrobial, antioxidant, hepatoprotective, and antidiabetic effects, demonstrating its potential in managing conditions like inflammation, cancer, infections, oxidative stress, liver

Read More »
June 26, 2025 No Comments