antibiotics Archives - Well Referenced

Extracorporeal Shockwave Therapy Combined with Drug Therapy in Chronic Pelvic Pain Syndrome: A Randomized Clinical Trial

This randomized clinical trial assessed the efficacy of combining extracorporeal shockwave therapy (ESWT) with pharmacotherapy in treating chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Thirty-one male patients were divided into two groups: the intervention group received a combination of an alpha-blocker, anti-inflammatory agent, muscle relaxant, a short course of antibiotics, and

June 26, 2025 No Comments

Intestinal microbiota in pathophysiology and management of irritable bowel syndrome

This 2014 review examines the role of intestinal microbiota in the pathophysiology and management of irritable bowel syndrome (IBS). It highlights that alterations in gut microbiota composition, known as dysbiosis, may contribute to IBS symptoms by affecting mucosal immunity, increasing epithelial permeability, and activating sensory-motor dysfunction. The review discusses potential

June 26, 2025 No Comments

Same Exposure but Two Radically Different Responses to Antibiotics: Resilience of the Salivary Microbiome versus Long-Term Microbial Shifts in Feces

This 2015 randomized, placebo-controlled study assessed how four common antibiotics (clindamycin, ciprofloxacin, amoxicillin, minocycline) affect the oral and gut microbiota in 66 healthy adults over a year. The study found that the salivary microbiome displayed high resilience, quickly reverting to baseline after antibiotic exposure. In contrast, the fecal microbiome exhibited

June 26, 2025 No Comments

How to Test and Treat Small Intestinal Bacterial Overgrowth: an Evidence-Based Approach

This 2016 review provides an evidence-based framework for diagnosing and managing Small Intestinal Bacterial Overgrowth (SIBO). Diagnosis methods include glucose and lactulose breath tests, as well as small intestinal aspiration and culture, though standardization issues exist. Treatment typically involves a two-week course of broad-spectrum antibiotics such as rifaximin, amoxicillin, or

June 26, 2025 No Comments

Oral Antibiotic Use in Adulthood and Risk of Early-Onset Colorectal Cancer: A Case-Control Study

This 2023 case-control study investigated the relationship between oral antibiotic use in adulthood and the risk of early-onset colorectal cancer (CRC) using data from UK primary care records between 1999 and 2011. Among 7,903 CRC cases (445 diagnosed before age 50) and 30,418 controls, antibiotic exposure was associated with a

June 26, 2025 No Comments

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious disease

This article explores the potential of antibiotics that target mitochondrial function in eradicating cancer stem cells across various tumor types. The study suggests that by targeting mitochondria, these antibiotics disrupt key cellular processes in cancer stem cells, effectively reducing tumor recurrence and resistance to conventional therapies. The review proposes a

June 26, 2025 No Comments

Bisphosphonate-related osteonecrosis of the jaw (BRONJ): 5 year experience in the treatment of 131 cases with ozone therapy

This study explored the use of ozone therapy in the treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ), a condition caused by bisphosphonates that can lead to jaw bone degeneration. Over five years, 131 BRONJ patients were treated with a combination of ozone therapy, minimally invasive surgery, and antibiotics. The

June 26, 2025 No Comments

Lessons Learned from a Rhode Island Academic Out-Patient Lyme and Tick-Borne Disease Clinic

This observational study reviewed 218 patient charts from a Rhode Island outpatient Lyme and tick-borne disease clinic, highlighting the challenges in diagnosing and managing post-treatment Lyme disease syndrome (PTLDS). Common symptoms included fatigue (66.5%), joint pain (58.2%), cognitive difficulties (32.1%), and headaches (27.9%). Over half of the patients with symptoms

June 26, 2025 No Comments

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