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Tag: amyloid-β

α-Lipoic Acid Has the Potential to Normalize Copper Metabolism, Which Is Dysregulated in Alzheimer’s Disease

This experimental study evaluates α-lipoic acid (LA) as a modulator of copper homeostasis in Alzheimer’s disease (AD). Through in vitro and in vivo models—including SH-SY5Y neuronal cells and Drosophila melanogaster expressing human Aβ—LA was found to promote intracellular copper uptake, potentially reversing the copper dyshomeostasis observed in AD. Supplementation with

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June 26, 2025 No Comments

Challenges and Opportunities of Metal Chelation Therapy in Trace Metals Overload-Induced Alzheimer’s Disease

This 2023 review examines the role of trace metal dyshomeostasis—particularly involving copper (Cu), zinc (Zn), and iron (Fe)—in Alzheimer’s disease (AD) pathogenesis. It highlights how abnormal accumulation of these metals contributes to amyloid-β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, and neuroinflammation. The study evaluates various chelating agents, such as deferoxamine,

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June 26, 2025 No Comments

Multiple Mechanisms Linking Type 2 Diabetes and Alzheimer’s Disease: Testosterone as a Modifier

This 2017 review explores the interconnected pathophysiology of type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD), highlighting shared mechanisms such as insulin resistance, lipid dysregulation, inflammation, and oxidative stress. The authors propose that low testosterone levels may exacerbate these conditions by impairing insulin signaling, increasing amyloid-β accumulation, and promoting

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June 26, 2025 No Comments