Well Referenced

Tag: Akt

Recent Progress on Nutraceutical Research in Prostate Cancer

This 2014 review highlights the potential of various nutraceuticals—such as isoflavones, indole-3-carbinol (I3C), 3,3′-diindolylmethane (DIM), lycopene, epigallocatechin-3-gallate (EGCG), and curcumin—in the prevention and treatment of prostate cancer (PCa). These compounds have been shown to modulate critical signaling pathways, including androgen receptor (AR), Akt, and NF-κB, which are involved in PCa

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June 26, 2025 No Comments

Lunasin sensitivity in non-small cell lung cancer cells is linked to suppression of integrin signaling and changes in histone acetylation

This 2014 study investigates the differential sensitivity of non-small cell lung cancer (NSCLC) cell lines to lunasin, a soy-derived peptide with anticancer properties. The research compares lunasin-sensitive H661 cells to resistant H1299 cells, revealing that lunasin internalization is higher in H661 cells. Lunasin interacts with integrins containing αv, α5, β1,

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June 26, 2025 No Comments

Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer: a prospective window of opportunity neoadjuvant study

This prospective single-arm “window of opportunity” trial evaluated the biological effects of short-term metformin administration in 39 non-diabetic women with early-stage breast cancer. Patients received 500 mg of metformin three times daily for at least two weeks between diagnostic biopsy and surgery. Metformin treatment led to significant reductions in tumor

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June 26, 2025 No Comments

Therapeutic potential of benfotiamine and its molecular targets

This review article explores the therapeutic potential of benfotiamine, a lipid-soluble derivative of thiamine (vitamin B1), highlighting its superior bioavailability and its ability to activate transketolase—an enzyme that diverts harmful glycolytic intermediates from pathways that lead to advanced glycation end products (AGEs), a key factor in diabetic vascular complications. Benfotiamine

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June 26, 2025 No Comments