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Tag: advanced glycation end-products

Molecular Mechanisms in Early Diabetic Kidney Disease: Glomerular Endothelial Cell Dysfunction

This comprehensive review elucidates the pivotal role of glomerular endothelial cell (GEC) dysfunction in the early stages of diabetic kidney disease (DKD). It highlights how hyperglycemia-induced reactive oxygen species (ROS) production leads to oxidative stress, damaging GECs and disrupting the glomerular filtration barrier. The article emphasizes the crosstalk between GECs

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June 26, 2025 No Comments

L-carnosine and its Derivatives as New Therapeutic Agents for the Prevention and Treatment of Vascular Complications of Diabetes

This review explores the potential of L-carnosine and its carnosinase-resistant derivatives in preventing and treating vascular complications in diabetes. L-carnosine acts as a scavenger of reactive carbonyl species (RCS), helping to reduce the formation of harmful advanced glycation end-products (AGEs) and advanced lipoxidation end-products (ALEs), both of which contribute to

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June 26, 2025 No Comments

Pluripotent protective effects of carnosine, a naturally occurring dipeptide

This review article explores the multifaceted protective effects of carnosine, a naturally occurring dipeptide found abundantly in the brain, muscles, and lens. It highlights carnosine’s antioxidant capabilities, its ability to scavenge reactive oxygen species and aldehydes, and its inhibition of protein glycation and DNA-protein cross-linking, which collectively prevent cellular damage.

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June 26, 2025 No Comments

The multifaceted therapeutic potential of benfotiamine

This article discusses the therapeutic effects of benfotiamine, a synthetic derivative of thiamine (vitamin B1), in reducing advanced glycation end products (AGEs), which contribute to complications like diabetic neuropathy, nephropathy, and retinopathy. Benfotiamine enhances transketolase activity, thus reducing AGE accumulation and preventing these complications. In addition to its AGE-related effects,

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June 26, 2025 No Comments

Therapeutic potential of benfotiamine and its molecular targets

This review article explores the therapeutic potential of benfotiamine, a lipid-soluble derivative of thiamine (vitamin B1), highlighting its superior bioavailability and its ability to activate transketolase—an enzyme that diverts harmful glycolytic intermediates from pathways that lead to advanced glycation end products (AGEs), a key factor in diabetic vascular complications. Benfotiamine

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June 26, 2025 No Comments

Carnosine protects proteins against methylglyoxal-mediated modifications

This in vitro study explores the potential of carnosine, a naturally occurring dipeptide, in protecting proteins from methylglyoxal (MG)-induced modifications, which are associated with the formation of advanced glycation end-products (AGEs) and diabetic complications. The research demonstrates that carnosine effectively inhibits MG-induced protein modifications and prevents AGE formation, suggesting it

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June 26, 2025 No Comments