Well Referenced

Category: Sexual Health & Hormone Optimization

Disorders of orgasm and ejaculation in men

The article “Disorders of Orgasm and Ejaculation in Men” explores the diagnosis and management of common male sexual dysfunctions, including premature ejaculation, inhibited ejaculation, anejaculation, retrograde ejaculation, and anorgasmia. It highlights the psychological, neurological, and hormonal factors contributing to these conditions and emphasizes a multidisciplinary approach to treatment, incorporating both

Read More »
June 26, 2025 No Comments

Associations of postmenopausal hormone therapy with metabolic syndrome among diabetic and non-diabetic women

The study titled “Associations of postmenopausal hormone therapy with metabolic syndrome among diabetic and non-diabetic women” (Maturitas, 2019, PMID: 30704569) is a cohort study examining the relationship between hormone therapy (HT) use and metabolic syndrome (MetS) in middle-aged postmenopausal Korean women, stratified by diabetes status. Findings indicate that HT use

Read More »
June 26, 2025 No Comments

Androgens and breast cancer risk

This article reviews the use of testosterone supplementation for libido enhancement in postmenopausal women, noting that while it provides benefits, there are concerns about its potential to increase breast cancer risk due to the conversion of testosterone into oestradiol. The article calls for more high-quality studies to assess long-term safety.

Read More »
June 26, 2025 No Comments

Breast cancer risk in postmenopausal women using testosterone in combination with hormone replacement therapy

This review article discusses the potential impact of combining testosterone with estrogen in hormone replacement therapy for postmenopausal women and its associated risks, including breast cancer. It emphasizes the need for careful evaluation when using testosterone therapy alongside estrogen, especially for women with low sexual desire disorder, highlighting the importance

Read More »
June 26, 2025 No Comments

Disorders of orgasm in women

The article “Disorders of Orgasm in Women” by Cindy M. Meston et al., published in the Journal of Sexual Medicine (PMID: 16422985), reviews Female Orgasmic Disorder (FOD), a condition characterized by persistent or recurrent delay or absence of orgasm following normal sexual excitement, leading to distress or interpersonal difficulty. The

Read More »
June 26, 2025 No Comments

Breast cancer risk with postmenopausal hormonal treatment

This article reviews the relationship between postmenopausal hormone therapy and breast cancer risk. It finds that estrogen alone may slightly reduce breast cancer risk, while combined estrogen-progestin therapy significantly increases it. Notably, current estrogen-progestin use is linked to a higher risk of lobular cancer than ductal cancer, although the risk

Read More »
June 26, 2025 No Comments

Androgens in women before and after the menopause and post bilateral oophorectomy: clinical effects and indications for testosterone therapy

This systematic review examines testosterone therapy for postmenopausal women, particularly those who have undergone bilateral oophorectomy. It highlights clinical evidence showing that testosterone therapy improves sexual desire, lean body mass, and bone mineral density. The therapy could be a crucial addition to hormone replacement for women suffering from androgen deficiency.

Read More »
June 26, 2025 No Comments

Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort

This observational study from the E3N-EPIC cohort investigated the relationship between various hormone replacement therapy (HRT) regimens and breast cancer risk. The study found that combining estrogens with synthetic progestins increased breast cancer risk, even for short durations, while transdermal estrogens with synthetic progestins also showed an elevated risk. However,

Read More »
June 26, 2025 No Comments

Do estradiol levels influence on the cognitive function during antidepressant treatments in post-menopausal women with major depressive disorder? A comparison with pre-menopausal women

This observational study examined the impact of estradiol (E2) levels on cognitive function during antidepressant treatment in 39 women with major depressive disorder (MDD), comparing pre-menopausal and post-menopausal groups. Over a 6-week period, cognitive function improved significantly across all participants (P=0.00001), but in post-menopausal women, higher E2 levels were strongly

Read More »
June 26, 2025 No Comments