Well Referenced

Category: Sexual Health & Hormone Optimization

Treatment of Diabetic Impotence with Umbilical Cord Blood Stem Cell Intracavernosal Transplant: Preliminary Report of 7 Cases

This 2010 pilot study assessed the safety and efficacy of intracavernosal injections of human umbilical cord blood stem cells (hUCBSCs) in seven male patients (ages 57–87) with type 2 diabetes mellitus and refractory erectile dysfunction (ED). Each patient received a single injection of 1.5×10⁷ hUCBSCs without immunosuppression. Over a 9-month

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June 26, 2025 No Comments

Erectile Dysfunction Treatment Using Stem Cells: A Review

This 2021 systematic review evaluated clinical studies on stem cell therapy (SCT) for erectile dysfunction (ED), highlighting its potential as a regenerative treatment. Various stem cell types—adipose-derived (ADSC), bone marrow-derived (BMSC), umbilical cord, and placental—have been administered primarily via intracavernosal injection. Clinical trials reported improvements in erectile function, with some

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June 26, 2025 No Comments

The Current Status of Stem-Cell Therapy in Erectile Dysfunction: A Review

This 2016 review by Reed-Maldonado and Lue examines the application of stem cell (SC) therapy for erectile dysfunction (ED). The authors discuss various types of stem cells, including adipose-derived, bone marrow-derived, and umbilical cord-derived stem cells, and their potential mechanisms in treating ED. The review highlights four clinical trials where

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June 26, 2025 No Comments

Lessons From the Testosterone Trial

This 2018 review by Snyder et al. summarizes findings from the Testosterone Trials (TTrials), a coordinated set of seven placebo-controlled, double-blind trials involving 788 men aged 65 and older with low testosterone levels. The trials assessed the effects of testosterone therapy on various health domains. Key findings include: increased sexual

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June 26, 2025 No Comments

Testosterone Replacement Therapy and Cardiovascular Disease

This review examines the evolving evidence on the cardiovascular safety of testosterone replacement therapy (TRT) in men with hypogonadism. While earlier observational studies raised alarms over increased cardiovascular risks—including myocardial infarction and stroke—recent randomized trials, particularly the TRAVERSE study, provide reassurance that TRT does not significantly increase the risk of

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June 26, 2025 No Comments

Effect of penile rehabilitation with low intensity extracorporeal shock wave therapy on erectile function recovery following robot-assisted laparoscopic prostatectomy

This study evaluated the impact of low-intensity extracorporeal shock wave therapy (LIESWT) as a penile rehabilitation strategy on sexual function (SF) recovery post-robot-assisted laparoscopic prostatectomy (RALP). Conducted at Hiroshima University, the study involved 16 patients receiving LIESWT (5 early intervention, 11 delayed) and 178 control patients without LIESWT. SF was

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June 26, 2025 No Comments

Does growth hormone replacement therapy reduce mortality in adults with growth hormone deficiency? Data from the Dutch National Registry of Growth Hormone Treatment in adults

This nationwide cohort study from the Netherlands analyzed the impact of growth hormone (GH) replacement therapy on mortality in adults with GH deficiency (GHD). The study included 2,229 GH-treated patients, 109 untreated patients, and 356 partially treated patients. Results showed that GH-treated men had mortality rates comparable to the general

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June 26, 2025 No Comments

Socioeconomic factors do not but GH treatment does affect mortality in adult-onset growth hormone deficiency

This nationwide registry study from Denmark investigated the impact of socioeconomic factors and growth hormone (GH) treatment on mortality in adults with adult-onset GH deficiency. The study included 276 patients with GH deficiency and 25,717 matched controls. Results indicated that GH-treated patients exhibited reduced all-cause and malignancy-related mortality compared to

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June 26, 2025 No Comments

Long-term safety of growth hormone—a combined registry analysis

This comprehensive analysis reviewed data from multiple growth hormone (GH) registries to assess the long-term safety of GH treatment in children and adults. The study found no increased risk of mortality, stroke, or new malignancies in GH-treated individuals without pre-existing risk factors. However, an elevated risk of secondary neoplasms was

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June 26, 2025 No Comments