Well Referenced

Category: Sexual Health & Hormone Optimization

Treatment of Diabetic Impotence with Umbilical Cord Blood Stem Cell Intracavernosal Transplant: Preliminary Report of 7 Cases

This 2010 pilot study assessed the safety and efficacy of intracavernosal injections of human umbilical cord blood stem cells (hUCBSCs) in seven male patients (ages 57–87) with type 2 diabetes mellitus and refractory erectile dysfunction (ED). Each patient received a single injection of 1.5×10⁷ hUCBSCs without immunosuppression. Over a 9-month

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June 26, 2025 No Comments

Erectile Dysfunction Treatment Using Stem Cells: A Review

This 2021 systematic review evaluated clinical studies on stem cell therapy (SCT) for erectile dysfunction (ED), highlighting its potential as a regenerative treatment. Various stem cell types—adipose-derived (ADSC), bone marrow-derived (BMSC), umbilical cord, and placental—have been administered primarily via intracavernosal injection. Clinical trials reported improvements in erectile function, with some

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June 26, 2025 No Comments

The Current Status of Stem-Cell Therapy in Erectile Dysfunction: A Review

This 2016 review by Reed-Maldonado and Lue examines the application of stem cell (SC) therapy for erectile dysfunction (ED). The authors discuss various types of stem cells, including adipose-derived, bone marrow-derived, and umbilical cord-derived stem cells, and their potential mechanisms in treating ED. The review highlights four clinical trials where

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June 26, 2025 No Comments

Lessons From the Testosterone Trial

This 2018 review by Snyder et al. summarizes findings from the Testosterone Trials (TTrials), a coordinated set of seven placebo-controlled, double-blind trials involving 788 men aged 65 and older with low testosterone levels. The trials assessed the effects of testosterone therapy on various health domains. Key findings include: increased sexual

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June 26, 2025 No Comments

Testosterone Replacement Therapy and Cardiovascular Disease

This review examines the evolving evidence on the cardiovascular safety of testosterone replacement therapy (TRT) in men with hypogonadism. While earlier observational studies raised alarms over increased cardiovascular risks—including myocardial infarction and stroke—recent randomized trials, particularly the TRAVERSE study, provide reassurance that TRT does not significantly increase the risk of

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June 26, 2025 No Comments

Effect of penile rehabilitation with low intensity extracorporeal shock wave therapy on erectile function recovery following robot-assisted laparoscopic prostatectomy

This study evaluated the impact of low-intensity extracorporeal shock wave therapy (LIESWT) as a penile rehabilitation strategy on sexual function (SF) recovery post-robot-assisted laparoscopic prostatectomy (RALP). Conducted at Hiroshima University, the study involved 16 patients receiving LIESWT (5 early intervention, 11 delayed) and 178 control patients without LIESWT. SF was

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June 26, 2025 No Comments

Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society Clinical Practice Guideline

This guideline provides comprehensive recommendations for diagnosing and managing adult growth hormone deficiency (GHD). It emphasizes that GHD can be congenital or acquired, often due to pituitary or hypothalamic lesions. Diagnosis typically requires stimulation testing, as random GH and IGF-1 levels are insufficient. GH replacement therapy is indicated for adults

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June 26, 2025 No Comments

Reversal of epigenetic aging and immunosenescent trends in humans

The TRIIM (Thymus Regeneration, Immunorestoration, and Insulin Mitigation) trial examined the effects of a one-year intervention using recombinant human growth hormone (rhGH), dehydroepiandrosterone (DHEA), and metformin on epigenetic aging and immune system function in nine healthy men aged 51–65. The study demonstrated a significant reversal in biological age by an

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June 26, 2025 No Comments

Testosterone replacement therapy and the risk of venous thromboembolism: A systematic review and meta-analysis of randomized controlled trials

This 2021 systematic review and meta-analysis evaluated the association between testosterone replacement therapy (TRT) and venous thromboembolism (VTE) risk by analyzing 13 randomized controlled trials encompassing 5,050 men. The pooled data indicated no significant increase in VTE risk among men receiving TRT compared to placebo (RR: 1.03; 95% CI: 0.49–2.14;

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June 26, 2025 No Comments