Well Referenced

Category: Pain Management

Managing pain and reducing inflammation for long-term health.

Effect of Leukocyte Concentration on the Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis

This meta-analysis evaluated the impact of leukocyte concentration in platelet-rich plasma (PRP) on clinical outcomes for knee osteoarthritis (KOA). Analyzing six randomized controlled trials and three prospective studies encompassing 1,055 patients, the study compared leukocyte-poor PRP (LP-PRP) and leukocyte-rich PRP (LR-PRP) against hyaluronic acid (HA) and placebo. LP-PRP demonstrated significantly

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June 26, 2025 No Comments

Effects and safety of the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the treatment of knee osteoarthritis: a systematic review and meta-analysis

This systematic review and meta-analysis evaluated the efficacy and safety of intra-articular injections of platelet-rich plasma (PRP) combined with hyaluronic acid (HA) compared to PRP or HA alone in treating knee osteoarthritis (KOA). The analysis included seven studies (five randomized controlled trials and two cohort studies) encompassing 941 patients. Results

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June 26, 2025 No Comments

Efficacy and safety of platelet-rich plasma combined with hyaluronic acid versus platelet-rich plasma alone for knee osteoarthritis: a systematic review and meta-analysis

This systematic review and meta-analysis evaluated 13 studies (9 randomized controlled trials and 4 cohort studies) encompassing 1,118 patients to compare the efficacy and safety of intra-articular injections of platelet-rich plasma (PRP) combined with hyaluronic acid (HA) versus PRP alone in treating knee osteoarthritis (KOA). The analysis found that while

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June 26, 2025 No Comments

Efficacy and safety of platelet-rich plasma injections for the treatment of osteoarthritis: a systematic review and meta-analysis of randomized controlled trials

This systematic review and meta-analysis evaluated 24 randomized controlled trials encompassing 1,344 patients to assess the efficacy and safety of platelet-rich plasma (PRP) injections for osteoarthritis (OA), including knee (KOA), hip (HOA), ankle (AOA), and temporomandibular joint (TMJOA) OA. PRP injections significantly improved pain scores in KOA (MD = –1.03),

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June 26, 2025 No Comments

Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials

This meta-analysis evaluated the efficacy of intra-articular platelet-rich plasma (PRP) injections in patients with symptomatic knee osteoarthritis (OA) by analyzing data from randomized controlled trials. The study found that PRP provided significant improvements in pain relief and functional outcomes compared to hyaluronic acid (HA) and saline. At 12 months post-injection,

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June 26, 2025 No Comments

A new strategy to tackle severe knee osteoarthritis: Combination of intra-articular and intraosseous injections of Platelet Rich Plasma

This 2016 review by Sánchez et al. explores a novel therapeutic approach for severe knee osteoarthritis (OA) involving the combined use of intra-articular and intraosseous platelet-rich plasma (PRP) injections. The authors propose that targeting both the joint space and subchondral bone may address the multifactorial nature of OA more effectively

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June 26, 2025 No Comments

Vitamin C and E Antioxidant Supplementation May Significantly Reduce Pain Symptoms in Endometriosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

This 2024 systematic review and meta-analysis, published in PLOS ONE, evaluated the efficacy of vitamin C and E supplementation in reducing pain symptoms associated with endometriosis. The analysis included randomized controlled trials that assessed the impact of these antioxidants on endometriosis-related pain. The findings suggest that supplementation with vitamins C

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June 26, 2025 No Comments

Palliative Vitamin C Application in Patients with Radiotherapy-Resistant Bone Metastases: A Retrospective Study

This 2015 retrospective study assessed the effects of intravenous vitamin C (ascorbic acid) in 39 patients with bone metastases unresponsive to radiotherapy. Patients received high-dose intravenous vitamin C, and outcomes measured included pain levels, performance status, and survival time. The study found that vitamin C administration was associated with reduced

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June 26, 2025 No Comments