Effects and safety of the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the treatment of knee osteoarthritis: a systematic review and meta-analysis

This systematic review and meta-analysis evaluated the efficacy and safety of intra-articular injections of platelet-rich plasma (PRP) combined with hyaluronic acid (HA) compared to PRP or HA alone in treating knee osteoarthritis (KOA). The analysis included seven studies (five randomized controlled trials and two cohort studies) encompassing 941 patients. Results