Well Referenced

Category: Inflammation & Autoimmune Health

Immune system regulation, chronic inflammation management, and prevention.

Inflammation, Oxidative Stress and Postoperative Atrial Fibrillation in Cardiac Surgery

This 2015 review by Zakkar et al., published in Pharmacology & Therapeutics, explores the mechanisms by which inflammation and oxidative stress contribute to postoperative atrial fibrillation (POAF) following cardiac surgery. The authors discuss how surgical procedures trigger systemic inflammatory responses and oxidative stress, leading to atrial structural and electrical remodeling.

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June 26, 2025 No Comments

Optimal Support of Wound Healing: New Insights

This 2020 review by Baron, Glatz, and Proksch, published in Dermatology, reevaluates the traditional linear model of wound healing—comprising inflammation, proliferation, and remodeling—by highlighting their overlapping and concurrent nature. The authors advocate for therapeutic strategies that simultaneously address all three phases to expedite recovery and minimize complications. Dexpanthenol, a pantothenic

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June 26, 2025 No Comments

Effects of Oral Antioxidants on Lesion Counts Associated with Oxidative Stress and Inflammation in Patients with Papulopustular Acne

This 2012 randomized, placebo-controlled clinical trial published in Journal of Clinical & Experimental Dermatology Research evaluated the efficacy of oral antioxidants—silymarin, N-acetylcysteine (NAC), and selenium—in treating papulopustular acne. Fifty-six patients with acne vulgaris were assigned to receive one of the antioxidants or a placebo over an eight-week period. The study

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June 26, 2025 No Comments

Selenium and Selenoproteins in Health

This 2023 review article in Biomolecules by Zhang, Li, and Wei provides a comprehensive overview of selenium’s role in human health, emphasizing its incorporation into selenoproteins that are pivotal for various physiological processes. Selenium, an essential trace element, is integral to the function of at least 25 known human selenoproteins,

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June 26, 2025 No Comments

Selenium, Selenoproteins, and Immunity

This 2018 review article in Nutrients by Avery and Hoffmann delves into the pivotal role of selenium and its incorporation into selenoproteins in modulating immune responses. Selenium, an essential trace element, is integral to the function of 25 known human selenoproteins, many of which are involved in antioxidant defense and

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June 26, 2025 No Comments

Low-dose naltrexone (LDN): A promising treatment in immune-related diseases and cancer therapy

This 2018 review article, published in International Immunopharmacology, explores the pharmacological functions and mechanisms of low-dose naltrexone (LDN) and its potential therapeutic applications in immune-related diseases and cancer. The authors discuss how LDN, administered at doses significantly lower than those used for addiction treatment, may act as an immunomodulator by

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June 26, 2025 No Comments

Low-dose naltrexone as a treatment for chronic fatigue syndrome

This 2020 case series, published in BMJ Case Reports, presents three patient experiences with low-dose naltrexone (LDN) for chronic fatigue syndrome (CFS). The patients, aged 37 to 63, reported varying degrees of symptom improvement, including enhanced energy, reduced post-exertional malaise, and improved mood. LDN was administered at doses ranging from

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June 26, 2025 No Comments

Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study

This 2009 single-blind, placebo-controlled crossover pilot study, published in Pain Medicine, investigated the effects of low-dose naltrexone (LDN) on fibromyalgia symptoms in ten women diagnosed with the condition. Participants underwent a 2-week baseline period, followed by 2 weeks of placebo, 8 weeks of 4.5 mg LDN daily, and a 2-week

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June 26, 2025 No Comments

Low-dose naltrexone use for the management of post-acute sequelae of COVID-19

This 2023 study, published in International Immunopharmacology, investigates the potential of low-dose naltrexone (LDN) in treating post-acute sequelae of COVID-19 (PASC), commonly known as long COVID. The researchers explored LDN’s immunomodulatory effects, particularly its ability to reduce neuroinflammation and modulate immune responses, which are believed to contribute to long COVID

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June 26, 2025 No Comments

Low-dose naltrexone rescues inflammation and insulin resistance associated with hyperinsulinemia

This 2020 study, published in the Journal of Biological Chemistry, investigates the effects of low-dose naltrexone (LDN) on inflammation and insulin resistance induced by hyperinsulinemia. Using in vitro models, the researchers demonstrated that LDN treatment reduced pro-inflammatory cytokine production and improved insulin signaling pathways. The findings suggest that LDN may

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June 26, 2025 No Comments