Well Referenced

Category: General Health

Foundational wellness and long-term health maintenance.

Growth response to growth hormone-releasing hormone(1-29)-NH2 compared with growth hormone

This study compared the effectiveness of growth hormone-releasing hormone (GHRH(1-29)-NH₂) with standard growth hormone (GH) therapy in promoting growth in children with hypothalamic growth hormone deficiency (GHD). High-dose GHRH(1-29)-NH₂ significantly increased height velocity, comparable to GH treatment, but had no effect on bone age development. GHRH(1-29)-NH₂ did not induce GH

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June 26, 2025 No Comments

Influence of dopaminergic, adrenergic and cholinergic blockade and TRH administration on GH responses to GRF 1-29

This study investigated the effects of dopaminergic, adrenergic, and cholinergic blockade, along with TRH administration, on growth hormone (GH) responses to growth hormone-releasing factor (GRF) 1-29. It was found that these neurotransmitter systems modulate GH secretion in response to GRF, and TRH administration also influenced GH release. The study highlights

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June 26, 2025 No Comments

Intranasal administration of growth hormone-releasing hormone(1-29)-NH2 in children with growth hormone deficiency: effects on growth hormone secretion and growth

This study explored the efficacy of intranasal growth hormone-releasing hormone (GHRH(1-29)-NH₂) in stimulating growth hormone secretion and improving growth in children with growth hormone deficiency. The results showed that intranasal GHRH(1-29)-NH₂ significantly increased GH secretion and improved linear growth, suggesting it could be a viable, non-invasive alternative to traditional GH

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June 26, 2025 No Comments

Lack of effect of muscarinic cholinergic blockade on the GH responses to GRF 1-29 and TRH in acromegalic subjects

This study investigated the role of muscarinic cholinergic receptors in regulating growth hormone (GH) secretion in acromegalic patients. The trial involved eight subjects who received GH-releasing factor (GRF 1-29) and thyrotropin-releasing hormone (TRH) tests, with and without pirenzepine, a muscarinic antagonist. The results showed that muscarinic cholinergic blockade did not

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June 26, 2025 No Comments

A pilot randomized controlled trial of major ozone autohemotherapy for patients with post-acute sequelae of COVID-19

This randomized controlled trial investigated the effects of major ozone autohemotherapy (O₃-MAH) on patients with post-acute sequelae of COVID-19 (PASC). Seventy-three patients were assigned to receive either O₃-MAH plus conventional therapy or conventional therapy alone. The O₃-MAH group showed significantly greater improvements in symptoms, pulmonary function, and inflammatory markers, particularly

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June 26, 2025 No Comments

A comparative study of growth hormone (GH) and GH-releasing hormone(1-29)-NH2 for stimulation of growth in children with GH deficiency

This 1993 randomized controlled trial titled “A Comparative Study of Growth Hormone (GH) and GH-Releasing Hormone(1-29)-NH₂ for Stimulation of Growth in Children with GH Deficiency” (Acta Paediatrica Supplement, DOI: [10.1111/j.1651-2227.1993.tb12834.x]*) evaluated 60 children with hypothalamic GH deficiency, comparing growth outcomes with either GH therapy or low- and high-dose GHRH(1-29)-NH₂ over

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June 26, 2025 No Comments

A pilot study for treatment of COVID-19 patients in moderate stage using intravenous administration of ozonized saline as an adjuvant treatment-registered clinical trial

This pilot randomized controlled trial evaluated the use of intravenous ozonized saline as an adjunctive treatment for moderate-stage COVID-19 patients. Sixty-four patients were randomly assigned to receive either ozonized saline (n=32) or standard treatment (n=32). The ozonized saline group showed significant improvements in oxygen saturation, reduction in inflammatory markers, and

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June 26, 2025 No Comments

Clinical utility of ozone therapy in dental and oral medicine

This review discusses the clinical utility of ozone therapy in dental and oral medicine, highlighting its use in treating conditions such as dental caries, gingivitis, periodontitis, temporomandibular joint disorders, and post-surgical pain. Ozone therapy is effective in eliminating bacteria, promoting wound healing, and reducing inflammation, making it a valuable, non-invasive

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June 26, 2025 No Comments

Effects of [norleucine27]growth hormone-releasing hormone (GHRH)(1-29)-NH2 administration on the immune system of aging men and women

This study investigates the effects of [norleucine27]growth hormone-releasing hormone (GHRH) (1-29)-NH2 on immune function in elderly adults. Conducted as a single-blind, randomized, placebo-controlled trial, it involved 19 healthy elderly participants (10 women, 9 men) receiving nightly subcutaneous injections of either placebo or GHRH analog for 16 weeks. The results demonstrated

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June 26, 2025 No Comments