This 2019 experimental study investigates how inhibition of the mammalian target of rapamycin (mTOR) pathway impedes colon cancer progression. The findings reveal that mTOR inhibition leads to the dephosphorylation of 4E-BP1, resulting in suppressed activity of eukaryotic translation initiation factor 4E (eIF4E). This suppression upregulates the expression of PUMA (p53
