This 2021 mechanistic study explores how supraphysiologic testosterone (SupraT) affects prostate cancer cells by initiating autophagy-driven processes. SupraT triggers ferritinophagy and nucleophagy, resulting in ferroptosis and degradation of damaged DNA. These mechanisms stimulate cytoplasmic nucleic acid sensors and activate NF-κB signaling, leading to increased secretion of chemokines and cytokines and
