This review article evaluates the effectiveness of nonnutritive adsorbent compounds—such as activated charcoal, bentonite, zeolite, and hydrated sodium calcium aluminosilicate (HSCAS)—in preventing the toxic effects of mycotoxins, particularly aflatoxins, in animal feed. These compounds bind mycotoxins in the gastrointestinal tract, reducing absorption and systemic toxicity, thereby improving animal health and