Evidence for Sugar Addiction: Behavioral and Neurochemical Effects of Intermittent, Excessive Sugar Intake

This 2008 review by Avena, Rada, and Hoebel examines whether sugar can elicit addictive behaviors and neurochemical changes similar to those caused by drugs of abuse. Using an animal model, the study identifies four key components of addiction—bingeing, withdrawal, craving, and cross-sensitization—demonstrated through intermittent, excessive sugar intake. Neurochemical analyses reveal