This 2018 single-arm, non-blinded intervention study evaluated the effects of daily 300 mg oral magnesium oxide supplementation over one month in 48 patients with essential hypertension whose antihypertensive therapy remained unchanged. Post-intervention, significant reductions in systolic (from 139.7 ± 15.0 to 130.8 ± 13.4 mmHg) and diastolic (from 88.0 ±