Aging and Immortality: Quasi-Programmed Senescence and Its Pharmacologic Inhibition

This 2006 review by Mikhail V. Blagosklonny introduces the "quasi-programmed" theory of aging, proposing that aging is an unintended continuation of developmental growth programs driven by pathways like mTOR. These hyperfunctional processes lead to age-related diseases and functional decline. The paper suggests that pharmacological inhibition of these pathways, particularly using