Insulin Resistance, Selfish Brain, and Selfish Immune System: An Evolutionarily Positively Selected Program Used in Chronic Inflammatory Diseases

This 2014 review by Rainer H. Straub proposes that insulin resistance (IR) is an evolutionarily conserved mechanism that reallocates energy to the brain and immune system during stress or inflammation. The "selfish brain" and "selfish immune system" models suggest that both systems can independently induce IR to prioritize their energy