Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natural Killer Cells From Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

This 2019 study, published in Frontiers in Immunology, investigates the effect of low-dose naltrexone (LDN) on the function of Transient Receptor Potential Melastatin 3 (TRPM3) ion channels in natural killer (NK) cells from patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The researchers found that TRPM3 channel activity was significantly impaired