Severe Dermatitis with Loss of Epidermal Langerhans Cells in Human and Mouse Zinc Deficiency

This 2012 study by Kawamura et al., published in the Journal of Clinical Investigation, investigates the effects of zinc deficiency on skin integrity and immune function in both humans and mice. The researchers observed that patients with acrodermatitis enteropathica, a genetic disorder causing zinc deficiency, exhibited severe dermatitis characterized by