Effectiveness of B Vitamins and Their Interactions with Aspirin in Improving Cognitive Functioning in Older People with Mild Cognitive Impairment: Pooled Post-Hoc Analyses of Two Randomized Trials

This pooled post-hoc analysis of two randomized placebo-controlled trials assessed the impact of B vitamin supplementation (vitamin B12, folic acid, with or without vitamin B6) on cognitive function and brain atrophy in 545 older adults with mild cognitive impairment (MCI). Over 24 months, B vitamin supplementation significantly reduced whole brain