Resveratrol attenuates ICAM-1 expression and monocyte adhesiveness to TNF-α-treated endothelial cells: evidence for an anti-inflammatory cascade mediated by the miR-221/222/AMPK/p38/NF-κB pathway

This study examined the anti-inflammatory effects of resveratrol, focusing on its ability to reduce ICAM-1 expression and monocyte adhesion in TNF-α-treated endothelial cells. Resveratrol achieved this by upregulating miR-221/222, activating AMPK, and inhibiting the p38 MAPK and NF-κB signaling pathways. In vivo experiments confirmed its effectiveness in reducing ICAM-1 expression