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Tag: p38 MAPK

Protoapigenone, a Novel Flavonoid, Inhibits Ovarian Cancer Cell Growth In Vitro and In Vivo

This 2008 study evaluates the anticancer potential of protoapigenone, a naturally occurring flavonoid isolated from fern species, in ovarian cancer models. In vitro, protoapigenone suppressed proliferation and colony formation of ovarian cancer cell lines (MDAH-2774 and SKOV3) by inducing apoptosis and G2/M cell cycle arrest. Mechanistically, it activated stress signaling

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June 26, 2025 No Comments

Melatonin: an inhibitor of breast cancer

This 2015 review examines melatonin’s multifaceted role in inhibiting breast cancer progression. Melatonin exerts cytostatic and cytotoxic effects on breast cancer cells, particularly through MT1 receptor-mediated suppression of estrogen receptor alpha (ERα) expression and activity. It disrupts tumor metabolism by inhibiting the Warburg effect, leading to decreased cell proliferation and

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June 26, 2025 No Comments

Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-kappaB and p38 MAPK in HMC-1 human mast cell line

This in vitro study investigated the effects of quercetin on human mast cells (HMC-1) stimulated to produce inflammatory cytokines. The researchers found that quercetin significantly inhibited the expression and production of TNF-α, IL-1β, IL-6, and IL-8 by attenuating the activation of NF-kappaB and p38 MAPK pathways—two major regulators of inflammation.

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June 26, 2025 No Comments

Resveratrol attenuates ICAM-1 expression and monocyte adhesiveness to TNF-α-treated endothelial cells: evidence for an anti-inflammatory cascade mediated by the miR-221/222/AMPK/p38/NF-κB pathway

This study examined the anti-inflammatory effects of resveratrol, focusing on its ability to reduce ICAM-1 expression and monocyte adhesion in TNF-α-treated endothelial cells. Resveratrol achieved this by upregulating miR-221/222, activating AMPK, and inhibiting the p38 MAPK and NF-κB signaling pathways. In vivo experiments confirmed its effectiveness in reducing ICAM-1 expression

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June 26, 2025 No Comments