This observational study (CALLISTO) evaluated the correlations between high-sensitivity C-reactive protein (hsCRP) and cardiovascular risk factors in 1,561 Korean adults with cardiovascular disease (CVD) or diabetes mellitus (DM). It found that hsCRP levels significantly correlated with age, BMI, HDL-C, LDL-C/HDL-C ratio, LDL-C/TC ratio, HDL-C/TC ratio, HDL-C/TG ratio, and TC/TG ratio,