High C-reactive protein levels are associated with oral hormonal menopausal therapy but not with intrauterine levonorgestrel and transdermal estradiol

This observational study examined the effects of different hormone replacement therapies (HRT) on C-reactive protein (CRP) levels, a marker of inflammation associated with cardiovascular disease. Women on oral HRT exhibited significantly higher CRP levels compared to those using intrauterine levonorgestrel combined with transdermal estradiol (LNG/TDE) or the control group, suggesting