This prospective observational study assessed the incidence and predictors of hair loss in 42 morbidly obese female patients undergoing laparoscopic sleeve gastrectomy (LSG). Over a 12-month postoperative period, 41% of patients reported hair loss. While mean serum zinc and iron levels remained within normal ranges, low levels of these micronutrients
This review article explores the antimicrobial roles of copper (Cu) and zinc (Zn) in innate immunity. It highlights how phagocytic immune cells, such as macrophages and neutrophils, utilize Cu and Zn to intoxicate engulfed bacterial pathogens. The article discusses the mechanisms by which these metals disrupt bacterial homeostasis, including interference
This review examines the involvement of metals—particularly aluminum, copper, and zinc—in the pathogenesis of Alzheimer’s disease (AD). It discusses how these metals may contribute to the aggregation and toxicity of beta-amyloid proteins. The article evaluates the potential of metal chelators, such as desferrioxamine and clioquinol, as therapeutic agents to mitigate
This 2005 review by Liu et al. explores the potential of nanoparticle-conjugated chelators as a novel therapeutic strategy for Alzheimer’s disease (AD). Traditional chelation therapies, such as desferrioxamine, have shown limited efficacy due to poor blood-brain barrier (BBB) permeability and systemic side effects. The authors propose that nanoparticles conjugated to
This 2023 review examines the role of trace metal dyshomeostasis—particularly involving copper (Cu), zinc (Zn), and iron (Fe)—in Alzheimer’s disease (AD) pathogenesis. It highlights how abnormal accumulation of these metals contributes to amyloid-β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, and neuroinflammation. The study evaluates various chelating agents, such as deferoxamine,
This comprehensive review explores the mechanisms by which arsenic and cadmium exert toxic effects, primarily through oxidative stress and interference with essential metal ions. The article highlights the role of antioxidants and thiol-containing compounds in mitigating these toxicities. Key antioxidants discussed include S-adenosylmethionine, lipoic acid, glutathione, selenium, zinc, N-acetylcysteine (NAC),
This 1999 study examined the effects of zinc on the growth of human prostate cancer cell lines LNCaP (androgen-sensitive) and PC-3 (androgen-independent). Exposure to physiological concentrations of zinc (100–1,000 ng/ml) resulted in significant growth inhibition in both cell lines, with LNCaP cells exhibiting greater sensitivity (IC50 ~100 ng/ml) compared to
This review examines the impact of oxidative stress (OS) on male infertility and the potential protective effects of antioxidants. OS, resulting from an imbalance between reactive oxygen species (ROS) and antioxidant defenses, can impair sperm function by causing lipid peroxidation, DNA damage, and apoptosis. The article discusses various antioxidants, including
This 2014 review article explores the roles of essential elements—zinc, magnesium, lithium, iron, calcium, and chromium—in the development and treatment of depression and anxiety. It highlights evidence from preclinical and clinical studies linking deficiencies in these elements to mood disorders and notes that supplementation may improve the efficacy of antidepressants
This in vitro study review investigates how the structural properties of pectin—a plant-derived polysaccharide—affect its interactions with divalent cations like calcium and zinc. Key factors influencing binding include pectin’s degree of methylesterification, molecular weight, and the distribution of galacturonic acid units, along with environmental variables such as pH and cation
