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Tag: Wistar rats​

Effect of Plant Extracts Combinations on TNF-α, IL-6 and IL-10 Levels in Serum of Rats Exposed to Acute and Chronic Stress

This animal study investigated the effects of two plant extract combinations, Antistress I and Antistress II, on cytokine levels in rats exposed to acute and chronic stress. The results showed that both combinations reduced pro-inflammatory cytokines (TNF-α and IL-6) and modulated the anti-inflammatory cytokine IL-10, with Antistress II having the

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June 26, 2025 No Comments

L-deprenyl protects against rotenone-induced, oxidative stress-mediated dopaminergic neurodegeneration in rats

This in vivo animal study investigated the neuroprotective effects of L-deprenyl against rotenone-induced dopaminergic neurodegeneration in rats. Rotenone, a mitochondrial complex-I inhibitor, induces oxidative stress and neuronal damage, mimicking Parkinson’s disease pathology. L-deprenyl treatment significantly reduced oxidative stress markers, preserved dopaminergic neurons in the substantia nigra, decreased lipid peroxidation, and

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June 26, 2025 No Comments