Well Referenced

Tag: vitamin D

Correction: Serum 25-Hydroxyvitamin D Concentrations ≥40 ng/ml Are Associated with >65% Lower Cancer Risk: Pooled Analysis of Randomized Trial and Prospective Cohort Study

This 2018 correction pertains to the 2016 study that pooled data from a randomized clinical trial and a prospective cohort to assess the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and cancer risk in women aged 55 and older. The original analysis demonstrated that women with serum 25(OH)D concentrations ≥40

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June 26, 2025 No Comments

The role of vitamin D in allergic rhinitis

This 2017 review explores the association between vitamin D and allergic rhinitis (AR). It discusses vitamin D’s role in immune regulation, including modulation of T-helper cell responses and cytokine production. The review highlights that while some studies suggest an inverse relationship between serum vitamin D levels and AR risk, findings

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June 26, 2025 No Comments

Vitamin A and D in allergy: from experimental animal models and cellular studies to human disease

This 2018 review explores the immunomodulatory roles of vitamins A and D in allergic diseases. Animal studies indicate that deficiencies in these vitamins exacerbate allergic symptoms and lung inflammation, while supplementation, particularly with vitamin D, can attenuate these effects. Active metabolites—retinoic acid (RA) from vitamin A and 1,25-dihydroxyvitamin D3 (VD3)

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June 26, 2025 No Comments

Vitamin D and Its Role as a Protective Factor in Allergy

This 2014 review examines the potential protective effects of vitamin D against allergic diseases such as asthma and allergic rhinitis. It highlights that vitamin D deficiency is prevalent in Europe and may be linked to increased allergy prevalence. Vitamin D influences immune responses by modulating T-helper cell activity, enhancing regulatory

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June 26, 2025 No Comments

NAFLD and nutraceuticals: a review of completed phase III and IV clinical trials

This 2023 systematic review analyzed 12 completed phase III and IV clinical trials registered on ClinicalTrials.gov, focusing on nutraceutical interventions for Nonalcoholic Fatty Liver Disease (NAFLD). The majority of studies investigated vitamin D (26.7%) and omega-3 fatty acids (20.0%), with others examining caffeine, chlorogenic acid, ginger, phosphatidylcholine, Trigonella foenum-graecum seed

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June 26, 2025 No Comments

Vitamin D and Marine Omega-3 Fatty Acid Supplementation and Incident Autoimmune Disease: VITAL Randomized Controlled Trial

This large-scale, randomized, double-blind, placebo-controlled trial investigated whether daily supplementation with vitamin D₃ (2000 IU) and/or marine omega-3 fatty acids (1000 mg) reduces the incidence of autoimmune diseases. Over a median follow-up of 5.3 years among 25,871 U.S. adults aged ≥50 (men) and ≥55 (women), vitamin D supplementation led to

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June 26, 2025 No Comments

Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline

This 2024 guideline updates the 2011 recommendations, focusing on vitamin D use for disease prevention in individuals without established indications for treatment or 25(OH)D testing. Key recommendations include: (1) Empiric vitamin D supplementation is suggested for children and adolescents aged 1–18 years to prevent nutritional rickets and potentially reduce respiratory

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June 26, 2025 No Comments