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Tag: vitamin B1

Supplemental thiamine as a practical, potential way to prevent Alzheimer’s disease from commencing

This article proposes that thiamine (vitamin B1) supplementation may serve as a preventive strategy against Alzheimer’s disease (AD) in elderly individuals who are cognitively normal but exhibit amyloid or tau deposition. Thiamine deficiency is common in older adults and is associated with several AD-related pathologies, including synaptic hypometabolism, mitochondrial dysfunction,

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June 26, 2025 No Comments

Therapeutic potential of benfotiamine and its molecular targets

This review article explores the therapeutic potential of benfotiamine, a lipid-soluble derivative of thiamine (vitamin B1), highlighting its superior bioavailability and its ability to activate transketolase—an enzyme that diverts harmful glycolytic intermediates from pathways that lead to advanced glycation end products (AGEs), a key factor in diabetic vascular complications. Benfotiamine

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June 26, 2025 No Comments

The effects of vitamin B1 on ameliorating the premenstrual syndrome symptoms

A double-blind, placebo-controlled clinical trial examined the effects of vitamin B1 on premenstrual syndrome (PMS) symptoms among 80 students at Jahrom University of Medical Sciences. Participants were randomly assigned to receive either vitamin B1 or a placebo. The study found that vitamin B1 significantly reduced both mental (35.08%) and physical

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June 26, 2025 No Comments