This 2014 retrospective audit evaluated the safety, tolerability, and efficacy of combination phentermine and topiramate therapy for weight maintenance in 103 patients at the Austin Health Weight Control Clinic. Patients initially achieved a 10% weight loss through a very low energy diet (VLED). Among them, 61 discontinued the combination therapy,
This 2006 review article examines the efficacy and considerations of Very Low Energy Diets (VLEDs) in obesity treatment. VLEDs provide between 450 and 800 kcal/day, delivering complete nutritional requirements. They induce rapid weight loss, typically 1.5–2.5 kg/week, through mechanisms like mild ketosis, which suppresses hunger and preserves lean body mass.
This umbrella review analyzed 19 meta-analyses and 16 intervention trials to evaluate the effectiveness of various diets on weight management and diabetes remission in adults with type 2 diabetes. Very low energy diets (VLEDs) providing 400–500 kcal/day for 8–12 weeks resulted in the greatest weight loss, averaging 6.6 kg more
