Well Referenced

Tag: vascular inflammation

Endothelial Dysfunction Induced by Cadmium and Mercury and its Relationship to Hypertension

This review article explores the mechanistic links between cadmium (Cd) and mercury (Hg) exposure, endothelial dysfunction, and hypertension. Both metals are shown to induce oxidative stress and reduce nitric oxide (NO) bioavailability, impairing endothelial-dependent vasodilation and promoting vascular stiffness. Cd and Hg disrupt calcium signaling, increase reactive oxygen species (ROS),

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June 26, 2025 No Comments

Natural Compound Resveratrol Attenuates TNF-Alpha-Induced Vascular Dysfunction in Mice and Human Endothelial Cells: The Involvement of the NF-κB Signaling Pathway

This study explored how resveratrol, a natural polyphenol, protects against TNF-α-induced vascular inflammation in human endothelial cells and mice. At physiologically relevant concentrations (as low as 1 μM), resveratrol significantly reduced monocyte adhesion, lowered expression of key inflammatory markers like MCP-1/CCL2 and ICAM-1, and inhibited NF-κB pathway activation. In mice,

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June 26, 2025 No Comments

Effects of local cryotherapy on systemic endothelial activation, dysfunction, and vascular inflammation in adjuvant-induced arthritis (AIA) rats

This study investigated the effects of local cryotherapy on vascular inflammation and endothelial dysfunction in a rat model of adjuvant-induced arthritis (AIA). The results showed that cryotherapy reduced arthritis severity, joint damage, and vascular inflammation by decreasing pro-inflammatory cytokines such as IL-6, TNF-α, and IL-1β. It also improved endothelial function,

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June 26, 2025 No Comments

L-arginine as a nutritional prophylaxis against vascular endothelial dysfunction with aging

This review explores the potential benefits of L-arginine supplementation in mitigating age-related vascular endothelial dysfunction. L-arginine plays a crucial role in nitrogen detoxification, immune function, growth hormone secretion, and insulin regulation. It serves as a substrate for nitric oxide synthase, promoting nitric oxide (NO) production, which enhances vasodilation and vascular

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June 26, 2025 No Comments

Associations between markers of inflammation and physiological and pharmacological levels of circulating sex hormones in postmenopausal women

This study, published in Menopause in 2010 (PMID: 20632462), investigated the relationship between sex hormone levels and inflammatory markers in postmenopausal women, both undergoing hormone therapy and not. Findings indicate that while hormone therapy can reduce vascular inflammation, oral estradiol therapy raises C-reactive protein (CRP), a marker of generalized inflammation.

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June 26, 2025 No Comments