Ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated mitochondrial translocation of cofilin-1
This study investigated the pro-apoptotic effects of ursolic acid (UA) on human prostate cancer LNCaP cells. UA treatment resulted in significant inhibition of cell proliferation and induction of apoptosis, as evidenced by increased activities of caspase-3 and caspase-9. Mechanistically, UA activated the ROCK1/PTEN signaling pathway, leading to the dephosphorylation and
June 26, 2025
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