This systematic review and meta-analysis examined urinary 8-hydroxy-2-deoxyguanosine (8-OHdG) as a biomarker for oxidative DNA damage, analyzing 84 studies with 128 subgroups. The study found a pooled geometric mean of 3.9 ng/mg creatinine for urinary 8-OHdG levels in healthy adults with a mean BMI ≤ 25, measured using chemical methods.
This observational study examined the impact of occupational and lifestyle factors on urinary 8-hydroxydeoxyguanosine (8-OHdG) levels, a biomarker of oxidative DNA damage. Findings indicated that individuals with specific occupational exposures to hazardous substances or certain lifestyle behaviors exhibited higher 8-OHdG concentrations, suggesting increased oxidative stress. Monitoring urinary 8-OHdG provides a
This observational study examined the effects of age, smoking, and other lifestyle factors on urinary levels of 7-methylguanine (m7G) and 8-hydroxydeoxyguanosine (8-OHdG), biomarkers of DNA methylation and oxidative DNA damage, respectively. Analyzing 215 healthy Japanese individuals, the study found that current smokers exhibited significantly higher urinary m7G levels (p <
This observational study investigated the relationship between lifestyle factors and oxidative stress biomarkers in 135 healthy Japanese adults aged 20 to 69 years. The findings showed that smokers had significantly higher urinary 8-hydroxydeoxyguanosine (8-OHdG) levels (p < 0.05), indicating increased oxidative DNA damage, while individuals who engaged in regular physical
