Gene expression data reveal common pathways that characterize the unifocal nature of ovarian cancer
This study analyzed gene expression and p53 mutations in matched pelvic and extra-pelvic tumor samples from 30 patients with advanced-stage serous ovarian cancer. Findings revealed identical p53 mutations and similar signaling pathway expressions across tumor sites, supporting a unifocal origin in the pelvis. Three molecular pathways—TGF-WNT/cytoskeleton remodeling, chemokines/cell adhesion, and
June 26, 2025
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