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Tag: tumorigenesis

Link between Obesity and Cancer: Role of Triglyceride/Free Fatty Acid Cycling

This 2014 review explores the mechanistic links between obesity and cancer, focusing on the role of triglyceride/free fatty acid (TG/FFA) cycling. Obesity-induced alterations in lipid metabolism lead to increased availability of FFAs, which can promote tumorigenesis through various pathways, including enhanced energy supply for rapidly proliferating cancer cells, modulation of

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June 26, 2025 No Comments

Mitochondrial-Stem Cell Connection: Providing Additional Explanations for Understanding Cancer

This review introduces the Mitochondrial-Stem Cell Connection (MSCC) hypothesis, suggesting that chronic oxidative phosphorylation (OxPhos) insufficiency in stem cells leads to the formation of cancer stem cells (CSCs) and drives tumorigenesis. The hypothesis explains metabolic alterations in cancer, where cells compensate for OxPhos deficiency by upregulating glycolysis and glutaminolysis. Dysfunctional

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June 26, 2025 No Comments