Well Referenced

Tag: Tumor Suppression

Protoapigenone, a Novel Flavonoid, Inhibits Ovarian Cancer Cell Growth In Vitro and In Vivo

This 2008 study evaluates the anticancer potential of protoapigenone, a naturally occurring flavonoid isolated from fern species, in ovarian cancer models. In vitro, protoapigenone suppressed proliferation and colony formation of ovarian cancer cell lines (MDAH-2774 and SKOV3) by inducing apoptosis and G2/M cell cycle arrest. Mechanistically, it activated stress signaling

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June 26, 2025 No Comments

Role of Melatonin in Cancer Treatment

This 2012 review explores melatonin’s multifaceted role in cancer therapy, highlighting its anti-proliferative, antioxidant, and immunomodulatory properties. Preclinical studies demonstrate melatonin’s ability to inhibit cancer cell proliferation, modulate estrogen receptor expression, and suppress tumor growth via antioxidant pathways. It also influences the expression of enzymes like aromatase, impacting estrogen biosynthesis.

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June 26, 2025 No Comments

Long-chain fatty acid analogues suppress breast tumorigenesis and progression

This 2014 study investigates the antitumor effects of MEDICA analogues, synthetic long-chain fatty acid derivatives, in breast cancer models. In the MMTV-PyMT mouse model, MEDICA treatment significantly reduced tumor growth and lung metastasis, promoting a more differentiated tumor phenotype. Mechanistically, MEDICA compounds elevated reactive oxygen species (ROS) levels, leading to

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June 26, 2025 No Comments

Low-dose naltrexone plays antineoplastic role in cervical cancer progression through suppressing PI3K/AKT/mTOR pathway

This 2021 study investigates the antitumor effects of low-dose naltrexone (LDN) on cervical cancer. LDN treatment upregulated the expression of the opioid growth factor receptor (OGFr) and suppressed the PI3K/AKT/mTOR signaling pathway, leading to reduced proliferation, migration, and invasion of cervical cancer cells in vitro. In vivo, LDN inhibited tumor

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June 26, 2025 No Comments

Epigenetic impacts of ascorbate on human metastatic melanoma cells

This 2014 study explores how pharmacological doses of ascorbate (vitamin C) impact the epigenetic landscape of human metastatic melanoma cells. Researchers found that high concentrations of ascorbate (8 mM) significantly inhibited DNA methyltransferase (DNMT) activity but had no effect on histone deacetylase (HDAC) function. Additionally, ascorbate treatment resulted in the

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June 26, 2025 No Comments

Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10

This study explores the effect of betulinic acid on estrogen receptor-negative (ER-negative) breast cancer cells both in vitro and in vivo. The findings show that betulinic acid inhibits cell growth by regulating Sp transcription factors and microRNA-27a, which in turn affects the expression of ZBTB10, a gene involved in tumor

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June 26, 2025 No Comments

DCA and cancer

The article “Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications” (Oxidative Medicine and Cellular Longevity, 2019, PMID: 31827705) reviews the potential of DCA in cancer therapy, discussing its mechanism of action in targeting cancer cell metabolism by shifting energy production from glycolysis to mitochondrial oxidation. It highlights DCA’s ability

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June 26, 2025 No Comments